Tropomyosin Movement on F-actin Analyzed by Energy Landscape Determination

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tropomyosin binding to F-actin induced by myosin heads.

Tropomyosin is a regulatory protein associated with F-actin in many actomyosin contractile systems. If in vitro conditions are such that tropomyosin binds only slightly to F-actin, then the addition of myosin heads can induce stoichiometric binding between them. This suggests that formation of rigor bonds between actin and myosin heads may cause some change in the actin, stabilizing the appropr...

متن کامل

Regulation of the actin filament by tropomyosin

Tropomyosin (Tm) binds along actin filaments and is a universal regulator of filament function. Mutations cause myopathies and certain forms are down-regulated in cancer cells. In muscle, with troponin Tm makes contraction Ca2+-dependent. In non-muscle cells Tm stabilizes actin filaments and protects them from branching, severing and most crosslinking. Tropomyosins enhance formin-nucleated poly...

متن کامل

Induction of nonpolymerizable tropomyosin binding to F-actin by troponin and its components.

Nonpolymerizable tropomyosin, in which 11 residues have been quantitatively cleaved from the COOH terminus of muscle tropomyosin (TM) by enzymic digestion, does not bind to F-actin. Binding is restored in the presence of troponin (Tn) and absence of Ca2+. The binding is stronger than for intact TM alone and shows residual cooperativity. In the presence of Ca2+, the binding is at least 10-fold w...

متن کامل

Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin

1 Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037 2 Program on Cell Adhesion, The Burnham Institute, La Jolla, CA 92037 3 Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218 4 Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway...

متن کامل

Tropomyosin keeps actin tough

Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2012

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2011.11.115