Tropomyosin Movement on F-actin Analyzed by Energy Landscape Determination
نویسندگان
چکیده
منابع مشابه
Tropomyosin binding to F-actin induced by myosin heads.
Tropomyosin is a regulatory protein associated with F-actin in many actomyosin contractile systems. If in vitro conditions are such that tropomyosin binds only slightly to F-actin, then the addition of myosin heads can induce stoichiometric binding between them. This suggests that formation of rigor bonds between actin and myosin heads may cause some change in the actin, stabilizing the appropr...
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Nonpolymerizable tropomyosin, in which 11 residues have been quantitatively cleaved from the COOH terminus of muscle tropomyosin (TM) by enzymic digestion, does not bind to F-actin. Binding is restored in the presence of troponin (Tn) and absence of Ca2+. The binding is stronger than for intact TM alone and shows residual cooperativity. In the presence of Ca2+, the binding is at least 10-fold w...
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1 Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037 2 Program on Cell Adhesion, The Burnham Institute, La Jolla, CA 92037 3 Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218 4 Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway...
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Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.115